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A Prospective Study of Dietary Fat and Risk of Prostate Cancer

Animal fat, but not vegetable fat, associated with higher risk of prostrate cancer

Method
Data was used from the Health Professionals Follow-up Study, which is a prospective cohort of 51529 U.S. men, aged 40 through 75, who completed a validated food-frequency questionnaire in 1986. We sent follow-up questionnaires to the entire cohort in 1988 and 1990 to document new cases of a variety of diseases and to update exposure information.
Results
Total fat consumption was directly related to risk of advanced prostate cancer (age- and energy-adjusted RR = 1.79, with 95% confidence interval [CI] = 1.04-3.07, for high versus low quintile of intake; P [trend] =.06). This association was due primarily to animal fat (RR = 1.63; 95% CI = 0.95-2.78; P [trend] =.08), but not vegetable fat. Red meat represented the food group with the strongest positive association with advanced cancer (RR = 2.64; 95% CI = 1.21-5.77; P =.02)