Age-adjusted female hip fracture incidence has been noted to be higher in industrialized countries than in nonindustrialized countries. A possible explanation that has received little attention is that elevated metabolic acid production associated with a high animal protein diet might lead to chronic bone buffering and bone dissolution. In an attempt to examine this hypothesis, cross-cultural variations in animal protein consumption and hip fracture incidence were examined.
When female fracture rates derived from 34 published studies in 16 countries were regressed against estimates of dietary animal protein, A strong positive association was found between female fracture rates and dietary protein consumption. Elevated metabolic acid production, associated with a high animal protein diet, might lead to chronic bone buffering and bone dissolution
Cross-cultural association between dietary animal protein and hip fracture: a hypothesis